
Do not run your system without an anti-virus. Alternatively, you should find another anti-virus to run in its place. If disabling it fixes the 0x80004005 error, we strongly recommend repairing/resetting Windows 10 so that Windows Defender can work without causing problems.

Tap the Win+R keyboard shortcut to open the run box.In safe mode, you should be able to send the message even if those files are corrupt. It’s possible that some files in your Outlook profile are corrupt and are preventing you from sending emails. Try to run Outlook in safe mode and send a message. If you’re getting the 0x80004005 error when trying to send/receive emails in the Outlook desktop app, try the following fixes.
#Email and app accounts error 0x80004005 update
Free up space on your Windows drive and try installing the update again.

Normally, it is the larger feature updates that require at least 20GB of free space on the Windows drive but if an update is failing with the 0x80004005 error, giving it more space can often fix the problem. Windows 10 updates need disk space to download and install.
